Structure of PDB 8r6c Chain p

Receptor sequence

>8r6cp (length=117) Species: 679895 (Escherichia coli BW25113)

ARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRR
QRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVF
DKVAFTALVEKAKAALA

3D structure

• PDB: 8r6c Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
• Chain: p
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	p	A2 R3 V4 K5 R6 G7 V8 I9 R11 R13 H14 K15 K16 K19 K22 G23 Y24 Y25 G26 A27 R28 R30 V31 Y32 R33 V34 F36 Q37 K41 A42 Y45 Y47 R48 D49 R50 R51 Q52 R53 K54 R55 Q56 F57 R58 Q59 W61 I62 N66 R70 S75 Y76 S77 N81 K84 D91 R92 K93	A1 R2 V3 K4 R5 G6 V7 I8 R10 R12 H13 K14 K15 K18 K21 G22 Y23 Y24 G25 A26 R27 R29 V30 Y31 R32 V33 F35 Q36 K40 A41 Y44 Y46 R47 D48 R49 R50 Q51 R52 K53 R54 Q55 F56 R57 Q58 W60 I61 N65 R69 S74 Y75 S76 N80 K83 D90 R91 K92

Gene Ontology

Molecular Function

• GO:0000900 mRNA regulatory element binding translation repressor activity
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0017148 negative regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8r6c, PDBe:8r6c, PDBj:8r6c
• PDBsum: 8r6c
• PubMed: 38826346
• UniProt: P0A7L3|RL20_ECOLI Large ribosomal subunit protein bL20 (Gene Name=rplT)