Structure of PDB 8gxs Chain p

Receptor sequence
>8gxsp (length=766) Species: 9606 (Homo sapiens) [Search protein sequence]
MMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRM
IHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMA
DHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSR
VKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRG
RVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILP
SLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSL
RKETILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG
LALAFHDGSVHIVHRLSLQTMAVFYSSVHLKAMQLSWTSLALVGIDSHGK
LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQ
SLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKL
FLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKT
EEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNLRPGHSFLRDGTSLGML
RELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGP
ASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRA
PPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIK
NCLCGGLWWRVPLSYP
3D structure
PDB8gxs Structures of +1 nucleosome-bound PIC-Mediator complex.
Chainp
Resolution4.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN p C798 C801 C827 C829 C723 C726 C752 C754
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0042809 nuclear vitamin D receptor binding
GO:0046966 nuclear thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxs, PDBe:8gxs, PDBj:8gxs
PDBsum8gxs
PubMed36201575
UniProtQ9Y2X0|MED16_HUMAN Mediator of RNA polymerase II transcription subunit 16 (Gene Name=MED16)

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