Structure of PDB 6t59 Chain o3

Receptor sequence

>6t59o3 (length=104) Species: 9986 (Oryctolagus cuniculus)

VNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQ
TKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKG
QVIQ

3D structure

• PDB: 6t59 TTC5 mediates autoregulation of tubulin via mRNA degradation.
• Chain: o3
• Resolution: 3.11 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	o3	V2 N3 P5 R8 R9 T10 F11 K13 G16 K17 H18 Y26 K28 G29 D31 S32 Y34 Q36 G37 R39 R43 K44 G47 Y48 G50 Q51 T52 K53 P54 I55 F56 R57 K58 K59 A60 K61 K64 K65 V67 K80 R81 M82 R87 C88 K89 K97 K98 K100	V1 N2 P4 R7 R8 T9 F10 K12 G15 K16 H17 Y25 K27 G28 D30 S31 Y33 Q35 G36 R38 R42 K43 G46 Y47 G49 Q50 T51 K52 P53 I54 F55 R56 K57 K58 A59 K60 K63 K64 V66 K79 R80 M81 R86 C87 K88 K96 K97 K99
BS02	ZN	o3	C12 C15 C77	C11 C14 C76

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6t59, PDBe:6t59, PDBj:6t59
• PDBsum: 6t59
• PubMed: 31727855
• UniProt: G1T040|RL36A_RABIT Large ribosomal subunit protein eL42 (Gene Name=RPL36A)