Structure of PDB 8i0p Chain o

Receptor sequence
>8i0po (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
VKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSD
NEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLV
ELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVK
LKERQEAEKMFK
3D structure
PDB8i0p Molecular Basis for the activation of Human spliceosome
Chaino
Resolution3.4 Å
3D
structure
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Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna o K151 L152 K150 L151
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030620 U2 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007283 spermatogenesis
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtP09661|RU2A_HUMAN U2 small nuclear ribonucleoprotein A' (Gene Name=SNRPA1)

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