Structure of PDB 8cqw Chain o

Receptor sequence

>8cqwo (length=233) Species: 5476 (Candida albicans) [Search protein sequence]

TLQKKEKAQQKTAEERAAAKKVRKAANKEKRKVIFDRAAAYQKEYTEAER
SVIKAKRDAKASNSYYVDAQPKLVFVVRIKGINKIPPKPRKVLQLLRLTQ
INAGVFVRLTKATSELIKLAEPYVAYGYPSLSTIRQLVYKRGFGKVNKQR
IALSDNAIIEANLGKFNILSIEDLIHEIYTVGPNFKQVSNFLWPFKLSNP
NGGFRARKFQHFIQGGDTGNREQFINALVKQMN

3D structure

PDB

8cqw Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.05 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	o	Q17 R24 R31 K32 N35 R39 R58 R65 K68 K88 G89 I90 N91 K92 P95 K96 K99 L103 R105 Q108 I109 N110 A120 E123 L127 S140 R143 K148 R149 K153 K156 Q157 R158 D163 K194 N198 K204 L205 S206 N207 P208 N209 G210 G211 F212 R215 K216 F217 K238	Q9 R16 R23 K24 N27 R31 R50 R57 K60 K80 G81 I82 N83 K84 P87 K88 K91 L95 R97 Q100 I101 N102 A112 E115 L119 S132 R135 K140 R141 K145 K148 Q149 R150 D155 K186 N190 K196 L197 S198 N199 P200 N201 G202 G203 F204 R207 K208 F209 K230
BS02	rna	o	K126 E129 R215 F217 Q218 H219 I221 Q222	K118 E121 R207 F209 Q210 H211 I213 Q214

External links

PDB	RCSB:8cqw, PDBe:8cqw, PDBj:8cqw
PDBsum	8cqw
PubMed
UniProt	A0A8H6BVN2

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