Structure of PDB 6fyx Chain o

Receptor sequence
>6fyxo (length=529) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
FRPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTVEPVVFKF
LEIGVELKKGKLLKDGLHQYKKLIQGSTEGLVSVGAVARKFIDLVESKIA
SEQTRADELQKQEIDAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVK
KTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSDADTLQRYLDQRFQQV
DVSVKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSG
DPLLHTTAWKKFYKLYSTNPRATEEEFKTYSSTIFLSAISTQLDEIPSIG
YDPHLRMYRLLNLDAKPTRKEMLQSIIEDESIYGKVDEELKELYDIIEVN
FDVDTVKQQLENLLVKLSSKTYFSQYIAPLRDVIMRRVFVAASQKFTTVS
QSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITIDHESAKVTFAKD
PAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIE
EAAAKKSAGRTAGGSSPATPATPATPATP
3D structure
PDB6fyx Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Chaino
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna o Q25 K64 Q20 K59
BS02 rna o A37 R38 R39 R41 W42 K77 L78 Q80 A32 R33 R34 R36 W37 K72 L73 Q75
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
Biological Process
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002183 cytoplasmic translational initiation
GO:0002188 translation reinitiation
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0000131 incipient cellular bud site
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0010494 cytoplasmic stress granule
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex
GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fyx, PDBe:6fyx, PDBj:6fyx
PDBsum6fyx
PubMed30475211
UniProtP38249|EIF3A_YEAST Eukaryotic translation initiation factor 3 subunit A (Gene Name=RPG1)

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