Structure of PDB 5mqf Chain o

Receptor sequence
>5mqfo (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
VLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFEL
AEDAAAAIDNMNESELFGRTIRVNLAQVYMDIKIGNKPAGRIQMLLPMTA
ENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKH
TGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQI
EAQGSKDGKPKQKVIIADCGEYV
3D structure
PDB5mqf Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Chaino
Resolution5.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna o A153 D273 V274 Q277 A89 D195 V196 Q199
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0008143 poly(A) binding
GO:0016018 cyclosporin A binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006355 regulation of DNA-templated transcription
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0034774 secretory granule lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mqf, PDBe:5mqf, PDBj:5mqf
PDBsum5mqf
PubMed28076346
UniProtQ9UNP9|PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E (Gene Name=PPIE)

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