Structure of PDB 8pw5 Chain n

Receptor sequence

>8pw5n (length=514) Species: 10090 (Mus musculus) [Search protein sequence]

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGD
DQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTV
GGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLF
SGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW
NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPP
PYHTFEEPTYVKVK

3D structure

PDB

8pw5 SCAF1 drives the compositional diversity of mammalian respirasomes.

Chain

Resolution

3.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	n	H240 H290 H291	H240 H290 H291
BS02	HEA	n	A24 G27 T31 R38 Y54 H61 A62 M65 I66 M69 G125 W126 Y371 F377 H378 L381 S382 M390 F425 R438 R439 Y440 V465	A24 G27 T31 R38 Y54 H61 A62 M65 I66 M69 G125 W126 Y371 F377 H378 L381 S382 M390 F425 R438 R439 Y440 V465
BS03	HEA	n	W126 W236 V243 I247 H290 H291 T316 G317 F348 G352 L353 G355 L358 S359 D364 H368 D369 V373 H376 F377 V380 L381 R438	W126 W236 V243 I247 H290 H291 T316 G317 F348 G352 L353 G355 L358 S359 D364 H368 D369 V373 H376 F377 V380 L381 R438
BS04	MG	n	H368 D369	H368 D369

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0001666	response to hypoxia
GO:0006119	oxidative phosphorylation
GO:0006979	response to oxidative stress
GO:0009060	aerobic respiration
GO:0021549	cerebellum development
GO:0046688	response to copper ion
GO:0051602	response to electrical stimulus
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0045277	respiratory chain complex IV

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8pw5, PDBe:8pw5, PDBj:8pw5
PDBsum	8pw5
PubMed	38575788
UniProt	P00397\|COX1_MOUSE Cytochrome c oxidase subunit 1 (Gene Name=Mtco1)

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