Structure of PDB 8ipx Chain n

Receptor sequence

>8ipxn (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]

SGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVY
KAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRI
RVMLYPSRI

3D structure

PDB

8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

4.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	n	S2 G3 R4 W6 K8 K15 R16 L18 R19 Q21 E23 H24 Y34 Y51 K52 K54 N55 T57 V58 P60 T67 R68 V69 W71 K73 T75 R76 H78 G79 N80 S81 R85 K87 R89 N91 P93 A94 K95 R100 R102 R109	S1 G2 R3 W5 K7 K14 R15 L17 R18 Q20 E22 H23 Y33 Y50 K51 K53 N54 T56 V57 P59 T66 R67 V68 W70 K72 T74 R75 H77 G78 N79 S80 R84 K86 R88 N90 P92 A93 K94 R99 R101 R108

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
PDBsum	8ipx
PubMed	37491604
UniProt	P18077\|RL35A_HUMAN Large ribosomal subunit protein eL33 (Gene Name=RPL35A)