Structure of PDB 6xkz Chain n

Receptor sequence

>6xkzn (length=471) Species: 272942 (Rhodobacter capsulatus SB 1003)

SKDEYFDGVIRAGVIATTFWGIVGFLVAVIIAFQLAFPALNLEFGNGMLN
FGRLRPLHTSAVIFAFGGNALIASAFYVVQRTSAARLFGGTALGWFVFWG
WQLIIVTAATSYLLGGSQGKEYAELNWHLDILVAIVWVAYLIAFLGTIFK
RKEPHIYVANWFYLSFIVTIAMLHIVNNLAVPVSIFGTKSVQLMAGVQDA
MTQWWYGHNAVGFFLTAGFLGMMYYFVPKQAERPVYSYKLSIVHFWALIF
LYIWAGPHHLHYTALPDWASTLGMVMSVILWMPSWGGMINGLMTLSGAWD
KLRTDPVIRMMVVSIGFYGMSTFEGPMMSIKAVNSLSHYTDWTIGHVHSG
ALGWNGMITFGMLYFLTPRLWGRSGLYSLKLVSWHFWLATIGIVLYASSM
WVSGIMEGLMWREVDAQGFLVNGFADTVGAKFPMNVVRGVGGVLYLTGGL
IMAYNLWATVAKQPKTANLAV

3D structure

• PDB: 6xkz Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
• Chain: n
• Resolution: 7.2 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEC	n	E177 W260 V267 Y308 H314 H315 L336 T378 G381 P382 M384 S385 H394 T399 H402 V403 G406 N411	E121 W204 V211 Y252 H258 H259 L280 T322 G325 P326 M328 S329 H338 T343 H346 V347 G350 N355
BS02	HEC	n	F81 A84 V85 A88 R111 H114 V118 E177 Y178 I400 V403 H404 A407 L408 Y452 R494 G498	F25 A28 V29 A32 R55 H58 V62 E121 Y122 I344 V347 H348 A351 L352 Y396 R438 G442
BS03	CU	n	H264 H314 H315	H208 H258 H259

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6xkz, PDBe:6xkz, PDBj:6xkz
• PDBsum: 6xkz
• PubMed: 33568648
• UniProt: D5ARP4