Structure of PDB 5on6 Chain n

Receptor sequence

>5on6n (length=156) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

SAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKR
VVYLKHLEDNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKF
NVEYFAKEEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDK
PHMLKF

3D structure

PDB

5on6 The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	n	S2 K5 K8 W9 Y10 A16 A17 L18 K19 K20 T21 R22 K23 A24 R26 Q28 G45 R46 F47 R48 N61 T62 F69 K70 N72 G73 P75 R77 R78 N80 R82 Y83 I130 Q157 A161 S162 N167	S1 K4 K7 W8 Y9 A15 A16 L17 K18 K19 T20 R21 K22 A23 R25 Q27 G44 R45 F46 R47 N60 T61 F68 K69 N71 G72 P74 R76 R77 N79 R81 Y82 I110 Q137 A141 S142 N147
BS02	MG	n	Q28 K29	Q27 K28

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5on6, PDBe:5on6, PDBj:5on6
PDBsum	5on6
PubMed	29429877
UniProt	Q02326\|RL6A_YEAST Large ribosomal subunit protein eL6A (Gene Name=RPL6A)

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