Structure of PDB 8bhf Chain m3

Receptor sequence

>8bhfm3 (length=293) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMI
VRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLAR
TTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQ
NVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPV
YEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA

3D structure

PDB

8bhf Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	m3	F3 V4 K5 V6 K10 A11 K14 R15 Y16 Q17 K19 R23 G26 T28 Y31 R35 L36 K43 Y44 K48 F113 M115 P139 G140 Y145 L146 L150 R152 T153 F160 P174 H175 S176 K178 R179 R268 S272 A274 Q275 D278 Q282 S286 R289 A290	F1 V2 K3 V4 K8 A9 K12 R13 Y14 Q15 K17 R21 G24 T26 Y29 R33 L34 K41 Y42 K46 F111 M113 P137 G138 Y143 L144 L148 R150 T151 F158 P172 H173 S174 K176 R177 R266 S270 A272 Q273 D276 Q280 S284 R287 A288
BS02	rna	m3	K10 F13 K14 Y16 V18 F20 R21 R22 R24 T28 Y30 R33 R50 I52 R54 T56 N57 R58 Q63 I69 E70 D72 I74 N94 Y95 R152 T155 G156 N157 K158 H198 Y207 Y210 Q222 F223 S224 Q225 Y226 Y253 K255 K256 R259 V261 W266 N267 R268 K270 M271 L273 K277 R279 V280 K284	K8 F11 K12 Y14 V16 F18 R19 R20 R22 T26 Y28 R31 R48 I50 R52 T54 N55 R56 Q61 I67 E68 D70 I72 N92 Y93 R150 T153 G154 N155 K156 H196 Y205 Y208 Q220 F221 S222 Q223 Y224 Y251 K253 K254 R257 V259 W264 N265 R266 K268 M269 L271 K275 R277 V278 K282

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8bhf, PDBe:8bhf, PDBj:8bhf
PDBsum	8bhf
PubMed	37653241
UniProt	P19949\|RL5_RABIT Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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