Structure of PDB 8y38 Chain l

Receptor sequence

>8y38l (length=135) Species: 1280 (Staphylococcus aureus)

PTINQLVRKPRQSKIKKSDSPALNKGFNSKKKKFTDLNSPQKRGVCTRVG
TMTPKKPNSALRKYARVRLSNNIEINAYIPGIGHNLQEHSVVLVRGGRVK
DLPGVRYHIVRGALDTSGVDGRRQGRSLYGTKKPK

3D structure

• PDB: 8y38 Synthetic macrolides overcoming MLS B K-resistant pathogens.
• Chain: l
• Resolution: 2.58 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	l	P2 N5 Q6 L7 R9 K10 R12 Q13 K18 N29 K32 L38 N39 S40 P41 Q42 K43 R44 N59 S60 A61 L62 R63 K64 S71 Y79 G82 I83 R96 G97 K101 D102 R107 G113 R123 R124 Q125 G126 R127 S128 Y130 T132 K133 K134	P1 N4 Q5 L6 R8 K9 R11 Q12 K17 N28 K31 L37 N38 S39 P40 Q41 K42 R43 N58 S59 A60 L61 R62 K63 S70 Y78 G81 I82 R95 G96 K100 D101 R106 G112 R122 R123 Q124 G125 R126 S127 Y129 T131 K132 K133

External links

• PDB: RCSB:8y38, PDBe:8y38, PDBj:8y38
• PDBsum: 8y38
• PubMed: 38992047
• UniProt: A0A133PZQ5