Structure of PDB 6pto Chain l

Receptor sequence
>6ptol (length=614) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIY
IDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPERVFQISF
FNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAI
VDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANE
IPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGKTT
EGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSDEINELKEMVKDEHIY
DKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGD
PSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAG
ALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNART
SILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTE
LASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEK
YKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAE
AYDLLRQSIIRVDV
3D structure
PDB6pto Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Chainl
Resolution7.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP l E657 R708 V797 E801 E431 R482 V571 E575
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:1902969 mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pto, PDBe:6pto, PDBj:6pto
PDBsum6pto
PubMed31589141
UniProtP53091|MCM6_YEAST DNA replication licensing factor MCM6 (Gene Name=MCM6)

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