Structure of PDB 8s8h Chain k

Receptor sequence

>8s8hk (length=470) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

GETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIG
HVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPE
PDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSG
AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREE
SALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPR
DFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRP
GIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLC
RADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLE
PNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEK
HWRLIGWATIKKGTTLEPIA

3D structure

PDB

8s8h Structural basis of AUC codon discrimination during translation initiation in yeast.

Chain

Resolution

4.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	k	F128 K129 F321 D322 V323 N324 K325 V337 S379 G397 G399 R408	F71 K72 F264 D265 V266 N267 K268 V280 S322 G340 G342 R351
BS02	MET	k	Y142 F381 E383 G397	Y85 F324 E326 G340

External links

PDB	RCSB:8s8h, PDBe:8s8h, PDBj:8s8h
PDBsum	8s8h
PubMed	39193907
UniProt	P32481\|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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