Structure of PDB 8rw1 Chain k

Receptor sequence

>8rw1k (length=470) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

GETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIG
HVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPE
PDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSG
AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREE
SALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPR
DFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRP
GIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLC
RADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLE
PNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEK
HWRLIGWATIKKGTTLEPIA

3D structure

PDB

8rw1 Structural basis of AUC codon discrimination during translation initiation in yeast.

Chain

Resolution

3.35 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	k	V126 F128 D130 D322 V323 N324 K325 P326 G327 K334 S379 F381 D386 R408	V69 F71 D73 D265 V266 N267 K268 P269 G270 K277 S322 F324 D329 R351
BS02	peptide	k	D159 D252 M254 Q263 I280 P282 L287 Y289 N290	D102 D195 M197 Q206 I223 P225 L230 Y232 N233
BS03	MET	k	Y142 F381 E383 I396 G397	Y85 F324 E326 I339 G340

External links

PDB	RCSB:8rw1, PDBe:8rw1, PDBj:8rw1
PDBsum	8rw1
PubMed	39193907
UniProt	P32481\|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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