Structure of PDB 8rc4 Chain k

Receptor sequence
>8rc4k (length=589) Species: 9606 (Homo sapiens) [Search protein sequence]
PEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYI
TQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICP
ILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIK
AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLI
TQSTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCIL
LETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFE
FKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMP
GYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQL
VGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPS
IPVGISLGLLKREMAQGLLPRLLHGTLIMKDSNFRLVSSEQALKELAEHQ
LRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLL
QAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQ
3D structure
PDB8rc4 Structural basis of Integrator-dependent RNA polymerase II termination
Chaink
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN k D72 H73 D178 H414 D71 H72 D177 H413
BS02 ZN k H68 H70 H157 D178 H67 H69 H156 D177
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rc4, PDBe:8rc4, PDBj:8rc4
PDBsum8rc4
PubMed38570683
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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