Structure of PDB 8oeq Chain k

Receptor sequence

>8oeqk (length=386) Species: 5476 (Candida albicans) [Search protein sequence]

SHRKYEAPRHGSLGFLPRKRAAKQRGRVKSFPKDVKSKPVALTAFLGYKA
GMTTIVRDLDRPGSKMHKREVVEAATVVDTPPMVVVGVVGYVETPRGLRS
LTTVWAEHLSEEVRRRFYKNWYKSKKKAFTKYSGKYATDAKQVETELARI
KKYASVVRVLAHTQIKKTPLSQKKAHLAEIQINGGSVSDKVDWAKEHFEK
EVSVDSVFEQDEMIDVIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVAC
IGAWHPANVNWTVARAGQNGYHHRTSINHKVYRVGKGTDEANGATEFDRT
KKTINPMGGFVRYGNVNNDFVLLKGSIPGVKKRVVTLRKSLYVDTSRRAV
EKVNLKWIDTASRFGKGRFQTPAEKHAFMGTLKKDL

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	k	S2 H3 R4 K5 E7 A8 P9 R10 H11 G12 S13 L14 G15 F16 L17 P18 R19 K20 R21 Q25 R26 K30 S31 M53 T54 T55 R62 P63 S65 A75 Y92 T95 P96 R97 L99 R100 S101 L102 T103 T104 W106 R116 R117 F118 Y119 K120 N121 Y123 K124 S125 K126 K128 A129 F130 K132 Y133 R150 K153 Y154 R159 Q173 K174 K175 L178 E180 T221 K222 G223 H224 G225 F226 E227 G228 H231 R232 K236 K237 R240 K241 T242 H243 R244 G245 L246 R247 K248 V249 A250 C251 I252 G253 A254 W255 H256 P257 A258 N259 V260 W262 T263 R266 A267 Q269 Y272 H274 R275 T276 I278 N279 G309 V312 R313 G315 S327 I328 P329 G330 K332 K333 R334 Y343 R348 S363 R364 F365 G366 K367 K376 M380 K384 K385	S1 H2 R3 K4 E6 A7 P8 R9 H10 G11 S12 L13 G14 F15 L16 P17 R18 K19 R20 Q24 R25 K29 S30 M52 T53 T54 R61 P62 S64 A74 Y91 T94 P95 R96 L98 R99 S100 L101 T102 T103 W105 R115 R116 F117 Y118 K119 N120 Y122 K123 S124 K125 K127 A128 F129 K131 Y132 R149 K152 Y153 R158 Q172 K173 K174 L177 E179 T220 K221 G222 H223 G224 F225 E226 G227 H230 R231 K235 K236 R239 K240 T241 H242 R243 G244 L245 R246 K247 V248 A249 C250 I251 G252 A253 W254 H255 P256 A257 N258 V259 W261 T262 R265 A266 Q268 Y271 H273 R274 T275 I277 N278 G308 V311 R312 G314 S326 I327 P328 G329 K331 K332 R333 Y342 R347 S362 R363 F364 G365 K366 K375 M379 K383 K384
BS02	MG	k	S363 G368 F370	S362 G367 F369
BS03	MG	k	P82 T164	P81 T163
BS04	MG	k	H3 R4	H2 R3

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	Q59LS1\|RL3_CANAL Large ribosomal subunit protein uL3 (Gene Name=RPL3)

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