Structure of PDB 7pks Chain k

Receptor sequence
>7pksk (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
PEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYI
TQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICP
ILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIK
AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLI
TESTYSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWE
RMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKA
FDRAFADNPGPMVVFATPGHAGQSLQIFRKWAGNEKNMVIMPMQVEYMSF
SAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPA
NGETVTLPTSPSIPVGISLGLLKREMAQGLLPRLLHGTLIMKESNFRLVS
SEQALKEL
3D structure
PDB7pks Structural basis of Integrator-mediated transcription regulation.
Chaink
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN k D72 H73 H414 D71 H72 H375
BS02 ZN k H68 H70 H157 H67 H69 H156
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pks, PDBe:7pks, PDBj:7pks
PDBsum7pks
PubMed34762484
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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