Structure of PDB 6qx2 Chain k

Receptor sequence
>6qx2k (length=188) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVE
KARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAH
IRTLLLTFFYRFMRPLIEAGYVYIAQPPKGLGEMNADQLWETTMNPEHRA
LLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYA
3D structure
PDB6qx2 Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Chaink
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna k G436 D437 R458 G459 D512 G21 D22 R43 G44 D97
BS02 dna k R458 K460 L462 N463 K466 R471 H515 V626 R629 R43 K45 L47 N48 K51 R56 H100 V174 R177
BS03 JK8 k R630 E634 R178 E182
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6qx2, PDBe:6qx2, PDBj:6qx2
PDBsum6qx2
PubMed30962087
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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