Structure of PDB 6om7 Chain k

Receptor sequence

>6om7k (length=84) Species: 9606 (Homo sapiens)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPK

3D structure

• PDB: 6om7 Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Chain: k
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	k	R20 R21 T59 T61 G62 R63 M64 R65 H66 L67 K68 Y71 R72 R73 F74 R79 E80 G81 T82	R19 R20 T58 T60 G61 R62 M63 R64 H65 L66 K67 Y70 R71 R72 F73 R78 E79 G80 T81
BS02	rna	k	T2 K3 G4 T5 S6 S7 F8 G9 K10 R11 R12 N13 K14 T15 H16 K25 H28 Q30 K36 R43 K44 R45 K46 Y47 N48 W49 S50 K52 R55 R56 Y71	T1 K2 G3 T4 S5 S6 F7 G8 K9 R10 R11 N12 K13 T14 H15 K24 H27 Q29 K35 R42 K43 R44 K45 Y46 N47 W48 S49 K51 R54 R55 Y70
BS03	ZN	k	C19 C34	C18 C33

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6om7, PDBe:6om7, PDBj:6om7
• PDBsum: 6om7
• PubMed: 31160784
• UniProt: P61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)