Structure of PDB 6olf Chain k

Receptor sequence

>6olfk (length=84) Species: 9606 (Homo sapiens)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPK

3D structure

• PDB: 6olf Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Chain: k
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	k	R20 T59 G62 R63 R65 H66 K68 R72 R73 F74 H76 R79 G81 T82 T83 P84	R19 T58 G61 R62 R64 H65 K67 R71 R72 F73 H75 R78 G80 T81 T82 P83
BS02	rna	k	T2 K3 G4 T5 S6 F8 G9 K10 R11 R12 N13 T15 H16 K25 H28 Q30 K36 R43 K44 K46 Y47 N48 W49 S50 K52 R55 R56 T58 Y71	T1 K2 G3 T4 S5 F7 G8 K9 R10 R11 N12 T14 H15 K24 H27 Q29 K35 R42 K43 K45 Y46 N47 W48 S49 K51 R54 R55 T57 Y70
BS03	ZN	k	C19 C22 C34	C18 C21 C33

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6olf, PDBe:6olf, PDBj:6olf
• PDBsum: 6olf
• PubMed: 31160784
• UniProt: P61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)