Structure of PDB 6lu8 Chain k

Receptor sequence

>6lu8k (length=128) Species: 9606 (Homo sapiens)

AALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKG
QILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAH
NVSSKNRKAIVERAAQLAIRVTNPNARL

3D structure

• PDB: 6lu8 Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
• Chain: k
• Resolution: 3.13 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	k	R5 K15 R16 T17 K18 F20 R22 H23 Q24 D26 V29 K30 I31 N34 W35 R36 K37 R39 I41 N43 R44 R47 R48 F49 K50 G51 Q52 N57 I58 G59 Y60 G61 S62 N63 K64 K65 K67 H68 P71 K83 E98 A100 H101 N102 S104 S105 R108 N124 N126 A127 R128	R4 K14 R15 T16 K17 F19 R21 H22 Q23 D25 V28 K29 I30 N33 W34 R35 K36 R38 I40 N42 R43 R46 R47 F48 K49 G50 Q51 N56 I57 G58 Y59 G60 S61 N62 K63 K64 K66 H67 P70 K82 E97 A99 H100 N101 S103 S104 R107 N123 N125 A126 R127
BS02	MG	k	S25 Y28	S24 Y27

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6lu8, PDBe:6lu8, PDBj:6lu8
• PDBsum: 6lu8
• PubMed: 32669547
• UniProt: P62910|RL32_HUMAN Large ribosomal subunit protein eL32 (Gene Name=RPL32)