Structure of PDB 3jap Chain k

Receptor sequence
>3japk (length=396) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKI
YKCQEEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDA
ALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQ
KSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISP
RLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTIQ
CKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGA
KGHLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEVLMVNIGSTATGA
RVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKK
3D structure
PDB3jap Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.
Chaink
Resolution4.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K113 S114 T137 H197
Catalytic site (residue number reindexed from 1) K16 S17 T40 H84
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna k F128 K129 K139 F321 V323 P326 F381 R408 A409 F31 K32 K42 F208 V210 P213 F262 R289 A290
BS02 MET k F321 F381 A382 E383 G397 F208 F262 A263 E264 G278
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031369 translation initiation factor binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jap, PDBe:3jap, PDBj:3jap
PDBsum3jap
PubMed26212456
UniProtP32481|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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