Structure of PDB 5lzw Chain jj

Receptor sequence

>5lzwjj (length=425) Species: 9606 (Homo sapiens)

LLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAY
AWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGA
AQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMD
QVNWQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSS
ELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKI
EAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDI
IKINVGCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSE
PAVIKRLISVLNKSTGEVTKKKPKFLTKGQNALVELQTQRPIALELYKDF
KELGRFMLRYGGSTIAAGVVTEIKE

3D structure

• PDB: 5lzw Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
• Chain: jj
• Resolution: 3.53 Å

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	jj	S274 T325	S15 T66

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0006417 regulation of translation
• GO:0007165 signal transduction
• GO:0032790 ribosome disassembly
• GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
• GO:0072344 rescue of stalled ribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:1990533 Dom34-Hbs1 complex

External links

• PDB: RCSB:5lzw, PDBe:5lzw, PDBj:5lzw
• PDBsum: 5lzw
• PubMed: 27863242
• UniProt: Q9Y450|HBS1L_HUMAN HBS1-like protein (Gene Name=HBS1L)