Structure of PDB 8a98 Chain j

Receptor sequence

>8a98j (length=80) Species: 347515 (Leishmania major strain Friedlin)

TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTP

3D structure

• PDB: 8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
• Chain: j
• Resolution: 2.46 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	j	T2 K3 G4 T5 S7 M8 Q10 R11 H12 G13 R14 T15 H16 R24 N25 S26 H28 Q30 R33 A35 R41 R45 R46 Y47 N48 W49 V51 K52 R56 R58 K79 T80	T1 K2 G3 T4 S6 M7 Q9 R10 H11 G12 R13 T14 H15 R23 N24 S25 H27 Q29 R32 A34 R40 R44 R45 Y46 N47 W48 V50 K51 R55 R57 K78 T79
BS02	rna	j	K3 T5 T6 M8 G9 Q10	K2 T4 T5 M7 G8 Q9
BS03	rna	j	R20 R21 C22 R44 T59 G60 G62 R63 C64 R65 Y66 L67 R72 R73 N76 H77 K79 T80	R19 R20 C21 R43 T58 G59 G61 R62 C63 R64 Y65 L66 R71 R72 N75 H76 K78 T79
BS04	ZN	j	C19 C22 C34 C37	C18 C21 C33 C36

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8a98, PDBe:8a98, PDBj:8a98
• PDBsum: 8a98
• PubMed: 38722744
• UniProt: E9AEH2