Structure of PDB 6fec Chain j

Receptor sequence

>6fecj (length=136) Species: 9606 (Homo sapiens) [Search protein sequence]

SLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKAD
RDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSA
LRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

3D structure

PDB

6fec Structure of a human cap-dependent 48S translation pre-initiation complex.

Chain

Resolution

6.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	j	H32 F34 N38 D39 F41 H43 G49 K50 E51 T52 R55 T57 G59 M60 K63 D65 R66 E68 R98 G102 N103 R104 P134 I135 P136 S137 D138 S139 T140 R141 R142 K143 G144 G145 R146 R147 G148 R149 R150 L151	H17 F19 N23 D24 F26 H28 G34 K35 E36 T37 R40 T42 G44 M45 K48 D50 R51 E53 R83 G87 N88 R89 P119 I120 P121 S122 D123 S124 T125 R126 R127 K128 G129 G130 R131 R132 G133 R134 R135 L136
BS02	rna	j	S70 P71	S55 P56

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum	6fec
PubMed	29401259
UniProt	P62263\|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)