Structure of PDB 7ls2 Chain i2

Receptor sequence

>7ls2i2 (length=103) Species: 10090 (Mus musculus)

VNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQ
TKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKG
QVI

3D structure

• PDB: 7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
• Chain: i2
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	i2	V2 N3 P5 R8 R9 F11 K17 H18 Y26 K28 G29 K30 S32 Y34 A35 Q36 G37 R39 R40 R43 K44 G47 Y48 G50 Q51 T52 K53 P54 I55 F56 K58 A60 K61 T63 K64 K65 K80 R81 A84 K86 C88 K89 K97 K98 K100	V1 N2 P4 R7 R8 F10 K16 H17 Y25 K27 G28 K29 S31 Y33 A34 Q35 G36 R38 R39 R42 K43 G46 Y47 G49 Q50 T51 K52 P53 I54 F55 K57 A59 K60 T62 K63 K64 K79 R80 A83 K85 C87 K88 K96 K97 K99
BS02	rna	i2	K38 Y41 K53 P54 I55	K37 Y40 K52 P53 I54
BS03	ZN	i2	C12 C15 C72 C77	C11 C14 C71 C76

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0008150 biological_process
• GO:0140236 translation at presynapse
• GO:0140242 translation at postsynapse

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0045202 synapse
• GO:0098793 presynapse
• GO:0098794 postsynapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
• PDBsum: 7ls2
• PubMed: 34815424
• UniProt: P83882|RL36A_MOUSE Large ribosomal subunit protein eL42 (Gene Name=Rpl36a)