Structure of PDB 8ekc Chain i

Receptor sequence

>8ekci (length=127) Species: 562 (Escherichia coli) [Search protein sequence]

NQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLE
LVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGF
VTRDARQVERKKVGLRKARRRPQFSKR

3D structure

PDB

8ekc Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.

Chain

Resolution

2.7 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	i	Y7 R11 K13 S14 R18 F20 G69 G70 G71 S73 Q75 R85 R95 R99 T105 R106 R109 Q110 V111 R113 K114 K115 G117 R119 K120 R122 R123 Q126 F127 K129	Y4 R8 K10 S11 R15 F17 G66 G67 G68 S70 Q72 R82 R92 R96 T102 R103 R106 Q107 V108 R110 K111 K112 G114 R116 K117 R119 R120 Q123 F124 K126
BS02	rna	i	K129 R130	K126 R127

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ekc, PDBe:8ekc, PDBj:8ekc
PDBsum	8ekc
PubMed	36546783
UniProt	P0A7X3\|RS9_ECOLI Small ribosomal subunit protein uS9 (Gene Name=rpsI)