Structure of PDB 7oqc Chain i

Receptor sequence

>7oqci (length=99) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

RPKHELSRAELEELEEFEFKHGPMSLINDAMVTRTPVIISLRNNHKIIAR
VKAFDRHCNMVLENVKELWTEKKNVINRERFISKLFLRGDSVIVVLKTP

3D structure

PDB

7oqc Structural insights into how Prp5 proofreads the pre-mRNA branch site.

Chain

Resolution

4.1 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	i	K10 H11 R15 L18 R49 N50 R63 H64 R97 D99	K3 H4 R8 L11 R42 N43 R56 H57 R88 D90

Gene Ontology

	Biological Process
GO:0000245	spliceosomal complex assembly
GO:0000387	spliceosomal snRNP assembly
GO:0000395	mRNA 5'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008150	biological_process
GO:0008380	RNA splicing
GO:0036261	7-methylguanosine cap hypermethylation
GO:1903241	U2-type prespliceosome assembly

	Cellular Component
GO:0000243	commitment complex
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005682	U5 snRNP
GO:0005685	U1 snRNP
GO:0005686	U2 snRNP
GO:0005687	U4 snRNP
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030532	small nuclear ribonucleoprotein complex
GO:0032991	protein-containing complex
GO:0034715	pICln-Sm protein complex
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0071001	U4/U6 snRNP
GO:0071004	U2-type prespliceosome
GO:0071011	precatalytic spliceosome
GO:0071013	catalytic step 2 spliceosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7oqc, PDBe:7oqc, PDBj:7oqc
PDBsum	7oqc
PubMed	34349264
UniProt	Q06217\|SMD2_YEAST Small nuclear ribonucleoprotein Sm D2 (Gene Name=SMD2)