Structure of PDB 6fyy Chain i

Receptor sequence

>6fyyi (length=121) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GKKNTKGGKKGRRGKNDSDGPKRELIYKEEGQEYAQITKMLGNGRVEASC
FDGNKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEAR
TLKNQGELPENAKINETDNFG

3D structure

PDB

6fyy Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.

Chain

Resolution

3.02 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	i	G2 K4 N5 G9 K10 K11 R13 R14 G15 K16 N17 K23 L42 G43 N44 G45 R46 M58 I61 R62 G63 K64 R66 K67 V69 W70 M71	G1 K3 N4 G8 K9 K10 R12 R13 G14 K15 N16 K22 L41 G42 N43 G44 R45 M57 I60 R61 G62 K63 R65 K66 V68 W69 M70
BS02	rna	i	K7 K11 K67 W70	K6 K10 K66 W69

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031369	translation initiation factor binding
GO:0043024	ribosomal small subunit binding

	Biological Process
GO:0001677	formation of translation initiation ternary complex
GO:0001731	formation of translation preinitiation complex
GO:0001732	formation of cytoplasmic translation initiation complex
GO:0002188	translation reinitiation
GO:0006412	translation
GO:0006413	translational initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex

External links

PDB	RCSB:6fyy, PDBe:6fyy, PDBj:6fyy
PDBsum	6fyy
PubMed	30475211
UniProt	P38912\|IF1A_YEAST Eukaryotic translation initiation factor 1A (Gene Name=TIF11)