Structure of PDB 5xtc Chain i

Receptor sequence

>5xtci (length=347) Species: 9606 (Homo sapiens)

MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNP
RSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMM
AMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLN
VNLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNM
TILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLS
LGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYST
SITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

3D structure

• PDB: 5xtc Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
• Chain: i
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLX	i	Y143 I346	Y143 I346

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0019901 protein kinase binding
• GO:0035255 ionotropic glutamate receptor binding

Biological Process

• GO:0001666 response to hypoxia
• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0009060 aerobic respiration
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0042776 proton motive force-driven mitochondrial ATP synthesis
• GO:0072593 reactive oxygen species metabolic process
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:5xtc, PDBe:5xtc, PDBj:5xtc
• PDBsum: 5xtc
• PubMed: 28844695
• UniProt: P03891|NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 (Gene Name=MT-ND2)