Structure of PDB 4d61 Chain i

Receptor sequence
>4d61i (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
KEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETW
YLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIG
GASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINK
MDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKE
QSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKL
ESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEE
EEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIE
EVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDF
PQMGRFTLRDEGKTIAIGKVLKLVPE
3D structure
PDB4d61 Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires.
Chaini
Resolution9.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K216 S217 T268 H291
Catalytic site (residue number reindexed from 1) K16 S17 T68 H91
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna i R233 T234 K237 M442 G443 R494 K496 R33 T34 K37 M242 G243 R294 K296
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4d61, PDBe:4d61, PDBj:4d61
PDBsum4d61
PubMed25601755
UniProtP15170|ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Gene Name=GSPT1)

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