Structure of PDB 3jap Chain i

Receptor sequence

>3japi (length=111) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

NTKGGKKGRRGKNDSDGPKRELIYKEEGQEYAQITKMLGNGRVEASCFDG
NKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEARTLK
NQGELPENAKI

3D structure

PDB

3jap Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.

Chain

Resolution

4.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	i	N5 K10 K11 R14 K16 N17 L42 G43 N44 R62 G63 K64 R66 V69 M71	N1 K6 K7 R10 K12 N13 L38 G39 N40 R58 G59 K60 R62 V65 M67
BS02	rna	i	K7 K10 R13 W70	K3 K6 R9 W66

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031369	translation initiation factor binding
GO:0043024	ribosomal small subunit binding

	Biological Process
GO:0001677	formation of translation initiation ternary complex
GO:0001731	formation of translation preinitiation complex
GO:0001732	formation of cytoplasmic translation initiation complex
GO:0002188	translation reinitiation
GO:0006412	translation
GO:0006413	translational initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex

External links

PDB	RCSB:3jap, PDBe:3jap, PDBj:3jap
PDBsum	3jap
PubMed	26212456
UniProt	P38912\|IF1A_YEAST Eukaryotic translation initiation factor 1A (Gene Name=TIF11)