Structure of PDB 8c6j Chain h

Receptor sequence
>8c6jh (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
EDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRP
TLKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGACENCGAMTHKK
KDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMK
IVEEYAKVDLAKRTLKAQKLLRIREDIAKYLRNLDPNSAYYDPKTRAMRE
NPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQ
ADPTKLELLYKSFKVKKEDFKEQQKE
3D structure
PDB8c6j Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
Chainh
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna h W33 R34 W3 R4
BS02 IHP h K166 R167 K136 R137
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030628 pre-mRNA 3'-splice site binding
GO:0046872 metal ion binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006886 intracellular protein transport
GO:0008380 RNA splicing
GO:0034605 cellular response to heat
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c6j, PDBe:8c6j, PDBj:8c6j
PDBsum8c6j
PubMed36867703
UniProtO95391|SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (Gene Name=SLU7)

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