Structure of PDB 7azy Chain h

Receptor sequence

>7azyh (length=169) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

QNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVR
TFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFG
IDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTT
KEDTVSWFKQKYDADVLDK

3D structure

PDB

7azy Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Chain

Resolution

2.877 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	h	V18 N20 S22 S48 R51 Y52 F57 I59 I65 H68 R92 R94 N95 A98 F104 G105 D107 G124 M125 D126 Y128 K142	V13 N15 S17 S43 R46 Y47 F52 I54 I60 H63 R87 R89 N90 A93 F99 G100 D102 G119 M120 D121 Y123 K137
BS02	rna	h	Q6 Q43 T44 V46 T70 R72 G135 R137 V138 R141 R143 T147 G149 N150 H152	Q1 Q38 T39 V41 T65 R67 G130 R132 V133 R136 R138 T142 G144 N145 H147

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7azy, PDBe:7azy, PDBj:7azy
PDBsum	7azy
PubMed	33990576
UniProt	Q3E757\|RL11B_YEAST Large ribosomal subunit protein uL5B (Gene Name=RPL11B)

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