Structure of PDB 6umh Chain h

Receptor sequence

>6umhh (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLVESGGGVVQPGRSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAV
ISFDGSIKYSVDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARDR
LNYYDSSGYYHYKYYGMAVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSG
GTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT
VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS

3D structure

PDB

6umh Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).

Chain

Resolution

2.15 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PDO	h	K160 Q188 S194	K160 Q188 S194
BS02	PDO	h	G151 T152	G151 T152

External links

PDB	RCSB:6umh, PDBe:6umh, PDBj:6umh
PDBsum	6umh
PubMed	32049005

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