Structure of PDB 6kva Chain h

Receptor sequence

>6kvah (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLVQSGAEVKKPGSSVKVSCKASGGTLSSYAISWVRQAPGQGPEWMGW
INPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRPDDTAVYYCASGY
CSRTRCYDYWGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFP
EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN
VNHKPSNTKVDKKVEP

3D structure

PDB

6kva Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.

Chain

Resolution

2.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	h	Y33 A34 S36 W51 N53 A98 G100 Y101 C102 W111	Y32 A33 S35 W50 N52 A97 G99 Y100 C101 W110

External links

PDB	RCSB:6kva, PDBe:6kva, PDBj:6kva
PDBsum	6kva
PubMed	33953162

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