Structure of PDB 8t0r Chain g

Receptor sequence
>8t0rg (length=699) Species: 9606 (Homo sapiens) [Search protein sequence]
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGASSVLEN
FVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLE
IEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPP
DIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRT
IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITA
ALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQ
IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRT
GLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYP
RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFIRKG
WLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRD
VEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAG
VYPEPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIF
SELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGNINT
3D structure
PDB8t0r Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission
Chaing
Resolution3.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP g S41 G43 S45 R59 G60 K206 D208 R237 S238 Q239 I242 S41 G43 S45 R59 G60 K206 D208 R237 S238 Q239 I242
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017 microtubule binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007032 endosome organization
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0031623 receptor internalization
GO:0048488 synaptic vesicle endocytosis
GO:0050804 modulation of chemical synaptic transmission
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0097494 regulation of vesicle size
GO:0099049 clathrin coat assembly involved in endocytosis
GO:0099050 vesicle scission
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0030117 membrane coat
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle
GO:0042583 chromaffin granule
GO:0042995 cell projection
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098684 photoreceptor ribbon synapse
GO:0098793 presynapse
GO:0098835 presynaptic endocytic zone membrane
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t0r, PDBe:8t0r, PDBj:8t0r
PDBsum8t0r
PubMed38663399
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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