Structure of PDB 8rbx Chain g

Receptor sequence

>8rbxg (length=886) Species: 9606 (Homo sapiens)

DANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLAD
VFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSK
DFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQ
LVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKR
LAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSG
TIAIKHYFRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLA
LEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVV
ETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRS
ATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIAR
QASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEE
NYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAF
SQLICTCNSLKTSPPPAIALQRCGRISNQMKQSMEEFRSLASRYGDLYQA
SFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHAD
SEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSF
QRYFFQKLQSTSIKLALSPPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQ
SVCLNVSSTLQSNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESS
VKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQ

3D structure

• PDB: 8rbx Structural basis of Integrator-dependent RNA polymerase II termination
• Chain: g
• Resolution: 4.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	g	R73 K105 V110 H112 S113 N114	R53 K85 V90 H92 S93 N94
BS02	peptide	g	N414 C452 A454 N522 G523 W524 Y527 R531 Q532 R535 L549 A554 S555 F558 W561 N612 Q792 R793 F796 Q797 K798	N383 C421 A423 N491 G492 W493 Y496 R500 Q501 R504 L518 A523 S524 F527 W530 N581 Q751 R752 F755 Q756 K757

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0000077 DNA damage checkpoint signaling
• GO:0006974 DNA damage response
• GO:0016180 snRNA processing
• GO:0034243 regulation of transcription elongation by RNA polymerase II
• GO:0034472 snRNA 3'-end processing
• GO:0071479 cellular response to ionizing radiation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005737 cytoplasm
• GO:0016604 nuclear body
• GO:0032039 integrator complex

External links

• PDB: RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
• PDBsum: 8rbx
• PubMed: 38570683
• UniProt: Q9NVH2|INT7_HUMAN Integrator complex subunit 7 (Gene Name=INTS7)