Structure of PDB 8t4s Chain f

Receptor sequence
>8t4sf (length=74) Species: 9606 (Homo sapiens) [Search protein sequence]
KKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECG
AGVFMASHFDRHYCGKCCLTYCFN
3D structure
PDB8t4s Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses.
Chainf
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna f K81 T86 T87 K89 K90 N91 K92 H93 R95 K97 K99 K104 R118 F131 A133 S134 H135 R138 Y140 C141 K143 C145 T147 K4 T9 T10 K12 K13 N14 K15 H16 R18 K20 K22 K27 R41 F54 A56 S57 H58 R61 Y63 C64 K66 C68 T70
BS02 ZN f C121 C126 C141 C144 C44 C49 C64 C67
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0016567 protein ubiquitination
GO:0019941 modification-dependent protein catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030666 endocytic vesicle membrane
GO:0031982 vesicle
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t4s, PDBe:8t4s, PDBj:8t4s
PDBsum8t4s
PubMed37733586
UniProtP62979|RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)

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