Structure of PDB 5t5h Chain f

Receptor sequence

>5t5hf (length=397) Species: 5693 (Trypanosoma cruzi)

EHPRHGHLGFLPRKRSRQIRGRVRSFPKDDPSQKPHLTSFMVFKAGMTHI
VRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKTIGTVW
AHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLKAFAKK
ADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAEKIELAKSLLEK
EVRIDSIFQQSETCDVCAVTKGHGFTGVVKRWGVACLPRKTHRGLRKVAC
IGAWHPARVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQATTTYD
LTAKSITPMGGFVGYGTVRNDYIMLKGSVAGPRRRVITLRRPMAPQTSRK
LTEQITLKFIDTSSKIGHGRFQTKKEKSQWFGPLKKDRIRREERLRK

3D structure

• PDB: 5t5h Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.
• Chain: f
• Resolution: 2.54 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	f	R245 K246 H248 H261 P262	R239 K240 H242 H255 P256
BS02	rna	f	E7 H8 P9 R10 H11 P18 R19 K20 R21 P83 R93 P96 V97 H109 K134 Q135 R138 R148 R169 K170 E207 R209 F231 G233 R237 A241 C242 L243 P244 R245 K246 T247 H248 R249 G250 L251 R252 K253 A255 C256 I257 G258 A259 W260 H261 A263 R264 V265 M266 T268 R271 A272 Q274 S295 M296 N326	E1 H2 P3 R4 H5 P12 R13 K14 R15 P77 R87 P90 V91 H103 K128 Q129 R132 R142 R163 K164 E201 R203 F225 G227 R231 A235 C236 L237 P238 R239 K240 T241 H242 R243 G244 L245 R246 K247 A249 C250 I251 G252 A253 W254 H255 A257 R258 V259 M260 T262 R265 A266 Q268 S289 M290 N320
BS03	rna	f	G12 H13 L14 G15 F16 L17 R19 K20 R23 R26 R30 S31 K50 M53 T54 H55 R62 P63 G64 S65 P75 Y92 H99 K100 T101 G103 T104 W106 F118 K120 L128 A129 F130 T131 K132 R133 R161 S184 E185 T226 K227 H229 Y267 H279 R280 T281 H282 L283 N284 K285 K332 G333 S334 V335 A336 G337 R339 R346 M349 R355 K371 I372 G373 H374	G6 H7 L8 G9 F10 L11 R13 K14 R17 R20 R24 S25 K44 M47 T48 H49 R56 P57 G58 S59 P69 Y86 H93 K94 T95 G97 T98 W100 F112 K114 L122 A123 F124 T125 K126 R127 R155 S178 E179 T220 K221 H223 Y261 H273 R274 T275 H276 L277 N278 K279 K326 G327 S328 V329 A330 G331 R333 R340 M343 R349 K365 I366 G367 H368
BS04	rna	f	R21 R116 R117 Y119 K120 N121 K123 Q124 S125 A126 N174 R175 G177 V178 K179 K180 K227 G228 G230 F231 Q274 Y277 M315 G316 V319 G320 G322 R325 P338 R340 R341 S370 I372 G373 K380 K383 F387 L390 K391 R394	R15 R110 R111 Y113 K114 N115 K117 Q118 S119 A120 N168 R169 G171 V172 K173 K174 K221 G222 G224 F225 Q268 Y271 M309 G310 V313 G314 G316 R319 P332 R334 R335 S364 I366 G367 K374 K377 F381 L384 K385 R388

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:5t5h, PDBe:5t5h, PDBj:5t5h
• PDBsum: 5t5h
• PubMed: 27791004
• UniProt: V5B599