Structure of PDB 8a3w Chain e

Receptor sequence

>8a3we (length=151) Species: 347515 (Leishmania major strain Friedlin)

IIDARKKAAESRKNRDDKRWKRVLANMDEEKRKKFHGVRGATRASLLKRT
GRKPDAVSMEATIHLSKLLKKKTFSKRAPLAIKRIKAFVGRLMKTKDNRI
DASLNTYIWHKGVKGVPGRVRVLIQRKSEHFYTVISNVPVASFKGLTTKT
V

3D structure

• PDB: 8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
• Chain: e
• Resolution: 2.89 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	e	K93 K105	K71 K83
BS02	rna	e	K46 K47 A63 R71 G73 T84 H86 K89 K92 R141 K174 G175 L176	K33 K34 A41 R49 G51 T62 H64 K67 K70 R119 K144 G145 L146
BS03	rna	e	K92 K93 K94 F96 R99 K136	K70 K71 K72 F74 R77 K114
BS04	rna	e	R74 K75 P76 D77 K116 K118 R121 I122 N127 W131 V135 H160 F161	R52 K53 P54 D55 K94 K96 R99 I100 N105 W109 V113 H130 F131

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
• PDBsum: 8a3w
• UniProt: E9AFF2