Structure of PDB 7s1h Chain e

Receptor sequence

>7s1he (length=75) Species: 562 (Escherichia coli) [Search protein sequence]

RNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLF
AKADGKVKFEVKGPKNRKFISIEAE

3D structure

PDB

7s1h Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.

Chain

Resolution

2.35 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	e	N12 R14 D15 S16 E17 A18 K19 R20 K24 F26 G27 E29 L32 A33 G34 S35 I36 R41 G42 T43 K44 H46 G54 R55 D56 H57 F60 F69 R77 K78	N2 R4 D5 S6 E7 A8 K9 R10 K14 F16 G17 E19 L22 A23 G24 S25 I26 R31 G32 T33 K34 H36 G44 R45 D46 H47 F50 F59 R67 K68
BS02	rna	e	K72 G73 P74 N76	K62 G63 P64 N66

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0043022	ribosome binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0001558	regulation of cell growth
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0042256	cytosolic ribosome assembly
GO:0090070	positive regulation of ribosome biogenesis
GO:1902626	assembly of large subunit precursor of preribosome

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7s1h, PDBe:7s1h, PDBj:7s1h
PDBsum	7s1h
PubMed	35165456
UniProt	P0A7L8\|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)