Structure of PDB 7opd Chain e

Receptor sequence
>7opde (length=711) Species: 9606 (Homo sapiens) [Search protein sequence]
RDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKV
SPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIM
IRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILL
LIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQ
RLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEH
LTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFG
TAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFI
NKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDV
FEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDM
ELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI
KLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLV
LLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEV
EDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDA
AIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERD
KDNPNQYHYVA
3D structure
PDB7opd Structural basis of human transcription-DNA repair coupling.
Chaine
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide e P520 I521 D522 L523 T524 V525 N526 I527 L528 E581 P472 I473 D474 L475 T476 V477 N478 I479 L480 E533
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0160072 ubiquitin ligase complex scaffold activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0016567 protein ubiquitination
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0034644 cellular response to UV
GO:0035019 somatic stem cell population maintenance
GO:0042110 T cell activation
GO:0042254 ribosome biogenesis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0051246 regulation of protein metabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opd, PDBe:7opd, PDBj:7opd
PDBsum7opd
PubMed34526721
UniProtQ13619|CUL4A_HUMAN Cullin-4A (Gene Name=CUL4A)

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