Structure of PDB 6lsr Chain e

Receptor sequence
>6lsre (length=129) Species: 9606 (Homo sapiens) [Search protein sequence]
AKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMV
MATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGE
MKGSAITGPVAKECADLWPRIASNAGSIA
3D structure
PDB6lsr Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
Chaine
Resolution3.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna e K13 R15 S17 G19 P21 A24 V25 I40 G44 K46 R48 L49 N50 R51 L52 K74 V76 R85 K86 F95 K2 R4 S6 G8 P10 A13 V14 I29 G33 K35 R37 L38 N39 R40 L41 K63 V65 R74 K75 F84
BS02 MG e I45 K46 I34 K35
Gene Ontology
Molecular Function
GO:0001223 transcription coactivator binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0070180 large ribosomal subunit rRNA binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006610 ribosomal protein import into nucleus
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0032986 protein-DNA complex disassembly
GO:0050821 protein stabilization
GO:0070314 G1 to G0 transition
GO:0072717 cellular response to actinomycin D
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1903450 regulation of G1 to G0 transition
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lsr, PDBe:6lsr, PDBj:6lsr
PDBsum6lsr
PubMed32669547
UniProtP62829|RL23_HUMAN Large ribosomal subunit protein uL14 (Gene Name=RPL23)

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