Structure of PDB 7ls2 Chain d2

Receptor sequence

>7ls2d2 (length=86) Species: 10090 (Mus musculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

3D structure

• PDB: 7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
• Chain: d2
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	d2	T2 K3 G4 T5 S6 S7 F8 G9 K10 R11 R12 N13 K14 T15 H16 K25 H28 Q30 R43 K44 R45 K46 Y47 N48 W49 K52 A53 R55 R56 T59 Y71 R75 E80	T1 K2 G3 T4 S5 S6 F7 G8 K9 R10 R11 N12 K13 T14 H15 K24 H27 Q29 R42 K43 R44 K45 Y46 N47 W48 K51 A52 R54 R55 T58 Y70 R74 E79
BS02	rna	d2	R20 R21 C22 G23 Y39 T59 G60 G62 R63 M64 R65 H66 L67 Y71 R72 F74 H76 R79 E80 G81 T82 P84 K85 K87	R19 R20 C21 G22 Y38 T58 G59 G61 R62 M63 R64 H65 L66 Y70 R71 F73 H75 R78 E79 G80 T81 P83 K84 K86
BS03	ZN	d2	C19 C22 C34	C18 C21 C33

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0140236 translation at presynapse
• GO:0140242 translation at postsynapse

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0045202 synapse
• GO:0098793 presynapse
• GO:0098794 postsynapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
• PDBsum: 7ls2
• PubMed: 34815424
• UniProt: Q9D823|RL37_MOUSE Large ribosomal subunit protein eL37 (Gene Name=Rpl37)