Structure of PDB 8sh9 Chain d

Receptor sequence
>8sh9d (length=520) Species: 9606 (Homo sapiens) [Search protein sequence]
RGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDV
TITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLD
SCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSAT
TSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI
DDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSD
YAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLN
KMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLN
GSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKK
RALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAEN
AGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSA
LTLATETVRSILKIDDVVNT
3D structure
PDB8sh9 Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller structure
Chaind
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP d L52 G53 P54 G105 T107 S108 N172 S173 G424 G425 V508 Q510 L34 G35 P36 G87 T89 S90 N154 S155 G406 G407 V490 Q492
BS02 AF3 d D73 D407 D55 D389
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:0090666 scaRNA localization to Cajal body
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0042470 melanosome
GO:0042995 cell projection
GO:0044297 cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sh9, PDBe:8sh9, PDBj:8sh9
PDBsum8sh9
PubMed37852256
UniProtP50991|TCPD_HUMAN T-complex protein 1 subunit delta (Gene Name=CCT4)

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