Structure of PDB 7yfe Chain d

Receptor sequence
>7yfed (length=1084) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
QCHVCSAVLFSPLDLDAHVASHGLHGRHITEFISSWQNHPIVQVSADVEN
RKTAQLLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYA
IQSPFPEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNT
ETLSVRGANPLMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANL
RSLPGPDAEKWYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMN
GAMSEWVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECAQGYV
TVTSPYAPSVNRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQDISV
LLQRISPLQIDPTIISNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSF
RVALAGWLYNGVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTD
PCAPVKAFMTLANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNI
QLISPIDAPILRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLL
PIDHQPANVTTPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVS
SMRGTLGKLKLIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRD
RVPTMVGVTRQSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKY
PPDLVTNVWYADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISET
QYPVDRYLDWIPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGD
PRMTQLAIQYQQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIA
RGDIIIGRVQSTHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAA
PMIRDETGMMVPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEM
GAYPYMLHYYDPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDIS
SAPAVQYIISTEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAP
PTQIQLPEVVDLYNVVTRYAYETPPITAVVMGVP
3D structure
PDB7yfe In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Chaind
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN d C183 H199 H203 C2 H18 H22
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7yfe, PDBe:7yfe, PDBj:7yfe
PDBsum7yfe
PubMed36469786
UniProtC9E874

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