Structure of PDB 7lbm Chain d

Receptor sequence
>7lbmd (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECG
TPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLE
EVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEA
LEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQ
HKDRSTQLEMALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDL
AGGYTSSLACHRALQDAFSGLFWQP
3D structure
PDB7lbm Structure of the human Mediator-bound transcription preinitiation complex.
Chaind
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN d C26 H28 C49 C26 H28 C49
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0007512 adult heart development
GO:0021591 ventricular system development
GO:0043066 negative regulation of apoptotic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051592 response to calcium ion
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005675 transcription factor TFIIH holo complex
GO:0070516 CAK-ERCC2 complex
GO:0070985 transcription factor TFIIK complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7lbm, PDBe:7lbm, PDBj:7lbm
PDBsum7lbm
PubMed33707221
UniProtP51948|MAT1_HUMAN CDK-activating kinase assembly factor MAT1 (Gene Name=MNAT1)

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